BACKGROUND:  Histamine intolerance
(HIT) is associated with an excess of histamine because of an impaired function
of the histamine-degrading enzyme diamine oxidase (DAO). The genetic background
of HIT is unknown yet.
METHODS:  Case-control association study of all haplotype
tagging and four previously reported DAO SNPs and one HNMT Single nucleotide
polymorphism with symptoms of HIT and DAO serum activity in 484 German
individuals including 285 patients with clinical symptoms of HIT and 199
cont...

BACKGROUND: Chronic spontaneous urticaria is a skin disorder that is difficult to manage and can last for years. 'Pseudoallergens' are substances that induce hypersensitive/intolerance reactions that are similar to true allergic reactions. They include food additives, vasoactive substances such as histamine, and some natural substances in fruits, vegetables and spices. Eliminating pseudoallergens from the diet can reduce symptom severity and improve patient quality of life. AIM: To assess the...