BACKGROUND. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficientlymetabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and p...

BACKGROUND:  Histamine intolerance
(HIT) is associated with an excess of histamine because of an impaired function
of the histamine-degrading enzyme diamine oxidase (DAO). The genetic background
of HIT is unknown yet.
METHODS:  Case-control association study of all haplotype
tagging and four previously reported DAO SNPs and one HNMT Single nucleotide
polymorphism with symptoms of HIT and DAO serum activity in 484 German
individuals including 285 patients with clinical symptoms of HIT and 199
cont...

OBJECTIVE: To evaluate the evidence regarding the disease concept of histamine intolerance as a state of inadequate histamine inactivation.
METHODS: Keyword-based systematic screening of the scientific literature and of public websites focusing on diagnostic and therapeutic procedures.
RESULTS: Histamine intolerance is commonly diagnosed based solely on subjective reporting of symptoms instead of following systematic diagnostic procedures based on objective laboratory and physical parameters. T...